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Article

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression.

Carcinogenesis - 22 Nov 2024

Graham Sarah, Dmitrieva Mariia, Vendramini-Costa Debora Barbosa, Francescone Ralph, Trujillo Maria A, Cukierman Edna, Wood Laura D

Abstract excerpt

This review explores the progression of pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and extrinsic microenvironmental influences. PanIN development begins with Kirsten rat sarcoma viral oncogene (KRAS) mutations driving PanIN initiation. Key additional mutations in cyclin-dependent kinase inhibitor 2A (CDKN2A), tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39514554
DOI: 10.1093/carcin/bgae064
PMCID: PMC12098012

Genes

CDKN2A
KRAS
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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