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Pancreatic Cancer

30 Jan 2008

Abstract excerpt

The past two decades have witnessed an explosion in our understanding of pancreatic cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and somatic gene mutations. The genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4, and these are accompanied by a substantial compendium of genomic and transcriptomic alterations that facilitate cell cycle...

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PMID: 18039136
DOI: 10.1146/annurev.pathmechdis.3.121806.154305

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