Article
Molecular pathology of pancreatic cancer.
Pathology international - 1 Jan 2014
Saiki Yuriko, Horii Akira
Abstract excerpt
By genomic and epigenomic screening techniques, substantial progress has been made in our understanding of pancreatic cancer. The comprehensive studies of the pancreatic cancer genome have revealed that most genetic alterations are identified to be associated with specific core signaling pathways including high-frequency mutated genes such as KRAS, CDKN2A, TP53, and SMAD4 along with several low-frequency mutated...
Topics
- Animals
- Disease Progression
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Mutation
- Pancreatic Neoplasms