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Article

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

25 Jul 2013

Abstract excerpt

Notch receptors play a role in skeletal development and homeostasis, and Notch activation in undifferentiated and mature osteoblasts causes osteopenia. In contrast, Notch activation in osteocytes increases bone mass, but the mechanisms involved and exact functions of Notch are not known. In this study, Notch1 and - 2 were inactivated preferentially in osteocytes by mating Notch1/2 conditional mice, where Notch...

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PMID: 23884415
DOI: 10.1074/jbc.m113.470492

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