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Article

Alteration of Notch signaling in skeletal development and disease.

Annals of the New York Academy of Sciences - 1 Mar 2010

Tao Jianning, Chen Shan, Lee Brendan

Abstract excerpt

Notch signaling is an evolutionarily conserved mechanism for specifying and regulating organogenesis and tissue renewal. Human and mouse genetic studies have demonstrated mutations in many components of the Notch signaling pathway that cause skeletal patterning defects. More recently, the in vivo effects of Notch signaling on osteoblast specification, proliferation, and differentiation have been demonstrated in...

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Identifiers

PMID: 20392245
DOI: 10.1111/j.1749-6632.2009.05307.x
PMCID: PMC2952341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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