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Article

Canonical Notch activation in osteocytes causes osteopetrosis

18 Nov 2015

Abstract excerpt

Activation of Notch1 in cells of the osteoblastic lineage inhibits osteoblast differentiation/function and causes osteopenia, whereas its activation in osteocytes causes a distinct osteopetrotic phenotype. To explore mechanisms responsible, we established the contributions of canonical Notch signaling (Rbpjκ dependent) to osteocyte function. Transgenics expressing Cre recombinase under the control of the dentin...

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PMID: 26578715
DOI: 10.1152/ajpendo.00395.2015

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