Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of Notch Signaling in Osteoclasts Improves Bone Regeneration and Healing

5 Jun 2019

Abstract excerpt

Owing to the central role of osteoclasts in bone physiology and remodeling, manipulation of their maturation process provides a potential therapeutic strategy for treating bone diseases. To investigate this, we genetically inhibited the Notch signaling pathway in the myeloid lineage, which includes osteoclast precursors, using a dominant negative form of MAML (dnMAML) that inhibits the transcriptional complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and osteoporosis research
Share to Bone health and treatments
Share to Bone Metabolism and Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31166033
DOI: 10.1002/jor.24384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of Notch Signaling in Osteoclasts Improves Bone Regeneration and HealingPMID 31166033Read ↗

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone RemodelingSemantic proximity Read ↗

Canonical Notch activation in osteocytes causes osteopetrosisSemantic proximity Read ↗

Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.Semantic proximity Read ↗

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorptionSemantic proximity Read ↗

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone HomeostasisSemantic proximity Read ↗

Advances in osteoclast biology: old findings and new insights from mouse modelsSemantic proximity Read ↗

The origins and roles of osteoclasts in bone development, homeostasis and repairSemantic proximity Read ↗

Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.Semantic proximity Read ↗

Notch signaling in osteoblasts.Semantic proximity Read ↗

The Bone Morphogenetic Protein Pathway: The Osteoclastic PerspectiveSemantic proximity Read ↗

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone HomeostasisSemantic proximity Read ↗

Advances in osteoclast biology resulting from the study of osteopetrotic mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.