Article
Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.
Journal of cellular physiology - 1 Sept 2017
Muguruma Yukari, Hozumi Katsuto, Warita Hiroyuki, Yahata Takashi, Uno Tomoko, Ito Mamoru, Ando Kiyoshi
Abstract excerpt
Adult bone mass is maintained through a balance of the activities of osteoblasts and osteoclasts. Although Notch signaling has been shown to maintain bone homeostasis by controlling the commitment, differentiation, and function of cells in both the osteoblast and osteoclast lineages, the precise mechanisms by which Notch performs such diverse and complex roles in bone physiology remain unclear. By using a...
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