Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osteoblast lineage-specific effects of notch activation in the skeleton.

Endocrinology - 1 Feb 2013

Canalis Ernesto, Parker Kristen, Feng Jian Q, Zanotti Stefano

Abstract excerpt

Transgenic overexpression of the Notch1 intracellular domain inhibits osteoblast differentiation and causes osteopenia, and inactivation of Notch1 and Notch2 increases bone volume transiently and induces osteoblastic differentiation. However, the biology of Notch is cell-context-dependent, and consequences of Notch activation in cells of the osteoblastic lineage at various stages of differentiation and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Osteoblasts
Share to Bone Development
Share to Bone Diseases, Metabolic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Osteocalcin

Share to Osteogenesis

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 23275471
DOI: 10.1210/en.2012-1732
PMCID: PMC3548181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osteoblast lineage-specific effects of notch activation in the skeleton.PMID 23275471Read ↗

Canonical Notch activation in osteocytes causes osteopetrosisSemantic proximity Read ↗

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone RemodelingSemantic proximity Read ↗

Notch signaling in osteoblasts.Semantic proximity Read ↗

The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.Semantic proximity Read ↗

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent.Semantic proximity Read ↗

Alteration of Notch signaling in skeletal development and disease.Semantic proximity Read ↗

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.Semantic proximity Read ↗

Notch 1 impairs osteoblastic cell differentiation.Semantic proximity Read ↗

From Stem Cells to Bone-Forming CellsSemantic proximity Read ↗

Osx-Cre Targets Multiple Cell Types besides Osteoblast Lineage in Postnatal MiceSemantic proximity Read ↗

Notch signaling and bone remodeling.Semantic proximity Read ↗

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.