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Article

Notch signaling and bone remodeling.

Current osteoporosis reports - 1 Jun 2013

Regan Jenna, Long Fanxin

Abstract excerpt

Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney...

Read the complete abstract on PubMed

Topics

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Share to Bone Remodeling
Share to Cell Differentiation
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Osteoblasts

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Share to Receptors, Notch

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 23519781
DOI: 10.1007/s11914-013-0145-4
PMCID: PMC3645324

Genes

NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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