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Article

Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort.

Radiology - 1 Jan 2022

Prescott Jeffrey W, Doraiswamy P Murali, Gamberger Dragan, Benzinger Tammie, Petrella Jeffrey R

Abstract excerpt

Background Pathologic evidence of Alzheimer disease (AD) is detectable years before onset of clinical symptoms. Imaging-based identification of structural changes of the brain in people at genetic risk for early-onset AD may provide insights into how genes influence the pathologic cascade that leads to dementia. Purpose To assess structural connectivity differences in cortical networks between cognitively normal...

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PMID: 34636637
DOI: 10.1148/radiol.2021210383
PMCID: PMC9127824

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