A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.

doi:10.1186/s12967-015-0392-5

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Article

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.

Journal of translational medicine - 15 Feb 2015

Mothe Beatriz, Hu Xintao, Llano Anuska, Rosati Margherita, Olvera Alex, Kulkarni Viraj, Valentin Antonio, Alicea Candido, Pilkington Guy R, Sardesai Niranjan Y, Rocafort Muntsa, Crespo Manel, Carrillo Jorge, Marco Andrés, Mullins James I, Dorrell Lucy, Hanke Tomáš, Clotet Bonaventura, Pavlakis George N, Felber Barbara K, Brander Christian

Abstract excerpt

BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. METHODS: To overcome this problem, we used a novel immunogen design approach that is based on functional T cell response data from more than 1,000 HIV-1 clade B and C infected...

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PMID: 25879820
DOI: 10.1186/s12967-015-0392-5
PMCID: PMC4336696

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