Article

PD-1 blockade enhances HIV-1 vaccine-induced CD8⁺ T-cell responses in PWH early ART-treated

2024-07-06

Abstract excerpt

Current HIV-1 therapeutic vaccines do not generate T-cell immune responses in people with HIV-1 (PWH) able to eradicate the virus or to broadly control viral replication. The expression of inhibitory receptors (IRs) may limit vaccine efficacy by reducing specific effector functions in vaccine-induced T-cells. Recently, the clinical use of antibodies targeting IRs or immune checkpoint blockade (ICB) has demonstrate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 560c3414-d76c-574b-89d2-c352a7a2ea15
DOI: 10.1101/2024.07.05.601669

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PD-1 blockade enhances HIV-1 vaccine-induced CD8⁺ T-cell responses in PWH early ART-treatedDOI 10.1101/2024.07.05.601669Read

Vaccine-induced gag-specific T cells are associated with reduced viremia after HIV-1 infection.Semantic proximity Read

A Phase I Randomized Therapeutic MVA-B Vaccination Improves the Magnitude and Quality of the T Cell Immune Responses in HIV-1-Infected Subjects on HAART.Semantic proximity Read

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.Semantic proximity Read

Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIVSemantic proximity Read

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.Semantic proximity Read

Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapySemantic proximity Read

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.Semantic proximity Read

MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccineSemantic proximity Read

Vaccine-induced CD8+ T cells control AIDS virus replicationSemantic proximity Read

Phenotypic and Functional Profile of HIV-Inhibitory CD8 T Cells Elicited by Natural Infection and Heterologous Prime/Boost VaccinationSemantic proximity Read

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and functionSemantic proximity Read

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral TherapySemantic proximity Read