Article
Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.
PloS one - 1 Jan 2013
Zhang Nenggang, Jiang Yunyun, Mao Qilong, Demeler Borries, Tao Yizhi Jane, Pati Debananda
Abstract excerpt
The cohesin complex is responsible for the fidelity of chromosomal segregation during mitosis. It consists of four core subunits, namely Rad21/Mcd1/Scc1, Smc1, Smc3, and one of the yeast Scc3 orthologs SA1 or SA2. Sister chromatid cohesion is generated during DNA replication and maintained until the onset of anaphase. Among the many proposed models of the cohesin complex, the 'core' cohesin subunits Smc1, Smc3,...
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