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A handcuff model for the cohesin complex

15 Dec 2008

Abstract excerpt

The cohesin complex is responsible for the accurate separation of sister chromatids into two daughter cells. Several models for the cohesin complex have been proposed, but the one-ring embrace model currently predominates the field. However, the static configuration of the embrace model is not flexible enough for cohesins to perform their functions during DNA replication, transcription, and DNA repair. We used...

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PMID: 19075111
DOI: 10.1083/jcb.200801157

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