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Article

Epimorphin is a novel regulator of the progesterone receptor isoform-a.

Cancer research - 15 Sept 2013

Bascom Jamie L, Radisky Derek C, Koh Eileen, Fata Jimmie E, Lo Alvin, Mori Hidetoshi, Roosta Neda, Hirai Yohei, Bissell Mina J

Abstract excerpt

Epimorphin/syntaxin-2 is a membrane-tethered protein localized extracellularly (Epim) and intracellularly (Stx-2). The extracellular form Epim stimulates morphogenic processes in a range of tissues, including in murine mammary glands where its overexpression in luminal epithelial cells is sufficient to drive hyperplasia and neoplasia. We analyzed WAP-Epim transgenic mice to gain insight into how Epim promotes...

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Source

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Identifiers

PMID: 23867473
DOI: 10.1158/0008-5472.CAN-13-0021
PMCID: PMC3783262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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