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Article

Revealing Progesterone's Role in Uterine and Mammary Gland Biology: Insights from the Mouse

1 Feb 2005

Abstract excerpt

Apart from distinguishing the in vivo effects of progesterone (P) from those of estrogen (E), the progesterone receptor knockout (PRKO) mouse has furnished unprecedented access to novel cell-signaling paradigms, hitherto unsuspected. Along with providing new cellular principles by which P influences proliferative and differentiative programs obligate for tissue development and tumor progression, the PRKO in...

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PMID: 15714387
DOI: 10.1055/s-2005-864031

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