Article
Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis.
Molecular and cellular biology - 1 Jan 2003
Kurisaki Tomohiro, Masuda Aki, Sudo Katsuko, Sakagami Junko, Higashiyama Shigeki, Matsuda Yoichi, Nagabukuro Akira, Tsuji Atsushi, Nabeshima Yoichi, Asano Masahide, Iwakura Yoichiro, Sehara-Fujisawa Atsuko
Abstract excerpt
Meltrin alpha (ADAM12) is a metalloprotease-disintegrin whose specific expression patterns during development suggest that it is involved in myogenesis and the development of other organs. To determine the roles Meltrin alpha plays in vivo, we generated Meltrin alpha-deficient mice by gene targeting. Although the number of homozygous embryos are close to the expected Mendelian ratio at embryonic days 17 to 18,...
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