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Article

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

The Journal of cell biology - 15 Sept 2003

Wiseman Bryony S, Sternlicht Mark D, Lund Leif R, Alexander Caroline M, Mott Joni, Bissell Mina J, Soloway Paul, Itohara Shigeyoshi, Werb Zena

Abstract excerpt

During puberty, mouse mammary epithelial ducts invade the stromal mammary fat pad in a wave of branching morphogenesis to form a complex ductal tree. Using pharmacologic and genetic approaches, we find that mammary gland branching morphogenesis requires transient matrix metalloproteinase (MMP) activity for invasion and branch point selection. MMP-2, but not MMP-9, facilitates terminal end bud invasion by...

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Identifiers

PMID: 12975354
DOI: 10.1083/jcb.200302090
PMCID: PMC2172848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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