Article
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
European heart journal - 1 Apr 2014
Meder Benjamin, Rühle Frank, Weis Tanja, Homuth Georg, Keller Andreas, Franke Jennifer, Peil Barbara, Lorenzo Bermejo Justo, Frese Karen, Huge Andreas, Witten Anika, Vogel Britta, Haas Jan, Völker Uwe, Ernst Florian, Teumer Alexander, Ehlermann Philipp, Zugck Christian, Friedrichs Frauke, Kroemer Heyo, Dörr Marcus, Hoffmann Wolfgang, Maisch Bernhard, Pankuweit Sabine, Ruppert Volker, Scheffold Thomas, Kühl Uwe, Schultheiss Hans-Peter, Kreutz Reinhold, Ertl Georg, Angermann Christiane, Charron Philippe, Villard Eric, Gary Françoise, Isnard Richard, Komajda Michel, Lutz Matthias, Meitinger Thomas, Sinner Moritz F, Wichmann H-Erich, Krawczak Michael, Ivandic Boris, Weichenhan Dieter, Gelbrich Goetz, El-Mokhtari Nour-Eddine, Schreiber Stefan, Felix Stephan B, Hasenfuß Gerd, Pfeufer Arne, Hübner Norbert, Kääb Stefan, Arbustini Eloisa, Rottbauer Wolfgang, Frey Norbert, Stoll Monika, Katus Hugo A
Abstract excerpt
AIMS: Dilated cardiomyopathy (DCM) is one of the leading causes for cardiac transplantations and accounts for up to one-third of all heart failure cases. Since extrinsic and monogenic causes explain only a fraction of all cases, common genetic variants are suspected to contribute to the pathogenesis of DCM, its age of onset, and clinical progression. By a large-scale case-control genome-wide association study we...
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