Article
Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy.
PLoS genetics - 21 Oct 2010
Stark Klaus, Esslinger Ulrike B, Reinhard Wibke, Petrov George, Winkler Thomas, Komajda Michel, Isnard Richard, Charron Philippe, Villard Eric, Cambien François, Tiret Laurence, Aumont Marie-Claude, Dubourg Olivier, Trochu Jean-Noël, Fauchier Laurent, Degroote Pascal, Richter Anette, Maisch Bernhard, Wichter Thomas, Zollbrecht Christa, Grassl Martina, Schunkert Heribert, Linsel-Nitschke Patrick, Erdmann Jeanette, Baumert Jens, Illig Thomas, Klopp Norman, Wichmann H-Erich, Meisinger Christa, Koenig Wolfgang, Lichtner Peter, Meitinger Thomas, Schillert Arne, König Inke R, Hetzer Roland, Heid Iris M, Regitz-Zagrosek Vera, Hengstenberg Christian
Abstract excerpt
Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. Monogenic forms of DCM are observed in families with mutations located mostly in genes encoding structural and sarcomeric proteins. However, strong evidence suggests that genetic factors also affect the susceptibility to idiopathic DCM. To identify risk alleles for non-familial forms of DCM, we carried out a case-control...
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