Article
Evaluation of Women With Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study.
Circulation. Genomic and precision medicine - 1 Apr 2026
Kransdorf Evan P, Jain Rashmi, Mead Jonathan O, Haas Garrie, Hofmeyer Mark, Ewald Gregory A, Diamond Jamie, Owens Anjali, Lowes Brian, Stoller Douglas, Tang W H Wilson, Drazner Mark H, Martin Cindy M, Shah Palak, Tallaj Jose, Katz Stuart, Jimenez Javier, Shore Supriya, Smart Frank, Wang Jessica, Gottlieb Stephen S, Judge Daniel P, Huggins Gordon S, Cowan Jason, Parker Patricia, Cao Jinwen, Hurst Natalie S, Jordan Elizabeth, Ni Hanyu, Kinnamon Daniel D, Hershberger Ray E
Abstract excerpt
BACKGROUND: Rare variant genetics have been associated with peripartum cardiomyopathy (PPCM), but the role of genetics remains unsettled. The study sought to compare dilated cardiomyopathy (DCM) genetic risk in first-degree relatives (FDRs) of female patients (probands) with DCM or PPCM to gain causal inference, and to assess DCM-relevant rare variant prevalence in DCM/PPCM probands and population controls....
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