Article
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
Circulation. Cardiovascular genetics - 1 Apr 2012
Davies Robert W, Wells George A, Stewart Alexandre F R, Erdmann Jeanette, Shah Svati H, Ferguson Jane F, Hall Alistair S, Anand Sonia S, Burnett Mary S, Epstein Stephen E, Dandona Sonny, Chen Li, Nahrstaedt Janja, Loley Christina, König Inke R, Kraus William E, Granger Christopher B, Engert James C, Hengstenberg Christian, Wichmann H-Erich, Schreiber Stefan, Tang W H Wilson, Ellis Stephen G, Rader Daniel J, Hazen Stanley L, Reilly Muredach P, Samani Nilesh J, Schunkert Heribert, Roberts Robert, McPherson Ruth
Abstract excerpt
BACKGROUND: Recent genome-wide association studies (GWAS) have identified several novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial infarction risk. However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered. METHODS AND RESULTS: We performed a discovery...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.