Article
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.
European heart journal - 21 May 2021
Garnier Sophie, Harakalova Magdalena, Weiss Stefan, Mokry Michal, Regitz-Zagrosek Vera, Hengstenberg Christian, Cappola Thomas P, Isnard Richard, Arbustini Eloisa, Cook Stuart A, van Setten Jessica, Calis Jorg J A, Hakonarson Hakon, Morley Michael P, Stark Klaus, Prasad Sanjay K, Li Jin, O'Regan Declan P, Grasso Maurizia, Müller-Nurasyid Martina, Meitinger Thomas, Empana Jean-Philippe, Strauch Konstantin, Waldenberger Melanie, Marguiles Kenneth B, Seidman Christine E, Kararigas Georgios, Meder Benjamin, Haas Jan, Boutouyrie Pierre, Lacolley Patrick, Jouven Xavier, Erdmann Jeanette, Blankenberg Stefan, Wichter Thomas, Ruppert Volker, Tavazzi Luigi, Dubourg Olivier, Roizes Gérard, Dorent Richard, de Groote Pascal, Fauchier Laurent, Trochu Jean-Noël, Aupetit Jean-François, Bilinska Zofia T, Germain Marine, Völker Uwe, Hemerich Daiane, Raji Ibticem, Bacq-Daian Delphine, Proust Carole, Remior Paloma, Gomez-Bueno Manuel, Lehnert Kristin, Maas Renee, Olaso Robert, Saripella Ganapathi Varma, Felix Stephan B, McGinn Steven, Duboscq-Bidot Laëtitia, van Mil Alain, Besse Céline, Fontaine Vincent, Blanché Hélène, Ader Flavie, Keating Brendan, Curjol Angélique, Boland Anne, Komajda Michel, Cambien François, Deleuze Jean-François, Dörr Marcus, Asselbergs Folkert W, Villard Eric, Trégouët David-Alexandre, Charron Philippe
Abstract excerpt
AIMS: Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. METHODS AND RESULTS: We conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population. We identified and replicated two new DCM-associated loci on chromosome 3p25.1 [lead single-nucleotide...
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