Article
A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31.1.
Human genetics - 1 Dec 2005
Schönberger Jost, Kühler Leif, Martins Elisabete, Lindner Tom H, Silva-Cardoso Jose, Zimmer Michael
Abstract excerpt
Inherited dilated cardiomyopathy (DCM) is a genetically and phenotypically very heterogeneous disease. DCM is caused by mutations in multiple genes encoding proteins that are involved in force generation, force transmission, energy production and several signalling pathways. Thus, the pathophysiology of heart failure is complex and not yet fully understood. Familial forms of DCM let the way to identify new key...
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