Article
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
European heart journal - 1 May 2011
Villard Eric, Perret Claire, Gary Françoise, Proust Carole, Dilanian Gilles, Hengstenberg Christian, Ruppert Volker, Arbustini Eloisa, Wichter Thomas, Germain Marine, Dubourg Olivier, Tavazzi Luigi, Aumont Marie-Claude, DeGroote Pascal, Fauchier Laurent, Trochu Jean-Noël, Gibelin Pierre, Aupetit Jean-François, Stark Klaus, Erdmann Jeanette, Hetzer Roland, Roberts Angharad M, Barton Paul J R, Regitz-Zagrosek Vera, Aslam Uzma, Duboscq-Bidot Laëtitia, Meyborg Matthias, Maisch Bernhard, Madeira Hugo, Waldenström Anders, Galve Enrique, Cleland John G, Dorent Richard, Roizes Gerard, Zeller Tanja, Blankenberg Stefan, Goodall Alison H, Cook Stuart, Tregouet David A, Tiret Laurence, Isnard Richard, Komajda Michel, Charron Philippe, Cambien François
Abstract excerpt
AIMS: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM. METHODS AND RESULTS: One thousand one hundred and seventy-nine DCM patients and 1108 controls contributed to the discovery phase. Pools of DNA...
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