Article
Uric acid-induced endoplasmic reticulum stress triggers phenotypic change in rat glomerular mesangial cells.
Nephrology (Carlton, Vic.) - 1 Oct 2013
Li Shasha, Zhao Fei, Cheng Shaoli, Wang Xinyang, Hao Yaning
Abstract excerpt
AIM: The aim of this study was to explore the contribution and the mechanism of uric acid (UA) to phenotypic change in rat glomerular mesangial cells. METHODS: Rat glomerular mesangial cells (HBZY-1) were exposed to UA (0.05 mmol/L to 0.4 mmol/L) for 24 h to 48 h. Subsequently, 4-phenyl butyric acid (4-PBA) (5 mg/dL) was added and 48 h incubation was performed. HBZY-1 cells exposed to UA (0.4 mmol/L) were...
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