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Article

Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2017

Huijuan Wang, Xiaoxu Chen, Rui Song, Xinghui Li, Beibei Tao, Jianchun Mao

Abstract excerpt

Hyperuricemia is associated with the development of chronic kidney disease. Epithelial-to-mesenchymal transition (EMT) induced by hyperuricemia is blamed for initiation of renal fibrosis, which is one of the main characters of hyperuricemic nephropathy. Qi-Zhu-Xie-Zhuo-Fang (QZXZF) has been employed clinically for many years to treat patients with hyperuricemic nephropathy, but the mechanism underlying the...

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PMID: 28463799
DOI: 10.1016/j.biopha.2017.04.031

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