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Article

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2016

Cao Ai-Li, Wang Li, Chen Xia, Wang Yun-Man, Guo Heng-Jiang, Chu Shuang, Liu Cheng, Zhang Xue-Mei, Peng Wen

Abstract excerpt

Endoplasmic reticulum (ER) stress, resulting from the accumulation of misfolded and/or unfolded proteins in ER membranes, is involved in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to investigate the role of ER stress inhibitors ursodeoxycholic acid (UDCA) and 4-phenylbutyrate (4-PBA) in the treatment of DN in db/db mice. Findings have revealed that diabetic db/db mice were more...

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Identifiers

PMID: 26999661
DOI: 10.1038/labinvest.2016.44

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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