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Article

HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the early stage of obstructive injury.

American journal of physiology. Renal physiology - 1 Jan 2015

Tian Shaojiang, Zhang Lansing, Tang Junming, Guo Xia, Dong Kun, Chen Shi-You

Abstract excerpt

Previous studies have indicated that macrophage phenotype diversity is involved in the progression of renal fibrosis. However, the factors facilitating M1 or M2 phenotypes and the function of these polarized macrophages in kidney injury and fibrosis remain largely unknown. In the present study, we found that macrophages accumulated in the kidney interstitium exhibited mainly as the M1 phenotype at the early stage...

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Source

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Identifiers

PMID: 25377911
DOI: 10.1152/ajprenal.00484.2014
PMCID: PMC4281691

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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