Article
Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma.
Genes, chromosomes & cancer - 1 Oct 2013
Ortiz-Cuaran Sandra, Cox David, Villar Stéphanie, Friesen Marlin D, Durand Geoffroy, Chabrier Amélie, Khuhaprema Thiravud, Sangrajrang Suleeporn, Ognjanovic Simona, Groopman John D, Hainaut Pierre, Le Calvez-Kelm Florence
Abstract excerpt
Over 100 single nucleotide polymorphisms (SNP) are validated in the TP53 tumor suppressor gene. They define haplotypes, which may differ in their activities. Therefore, mutation in cancer may occur at different rates depending upon haplotypes. However, these associations may be masked by differences in mutations types and causes of mutagenesis. We have analyzed the associations between 19 SNPs spanning the TP53...
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