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Genome-wide association study of TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and hepatitis B virus infection in Guangxi

2020-08-03

Abstract excerpt

<h4>Background/Aims</h4> Dietary aflatoxin B1 (AFB1) exposure, which induces DNA damage and codon 249 mutation of the TP53 gene, is one of the major risk factors for hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) infection and AFB1 exert synergistic effects to promote carcinogenesis and TP53 R249S mutation in HCC. <h4>Methods</h4> A genome-wide association study (GWAS) was conducted on 485 cases of HCC...

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Literature Corpus work
bedfc21a-2132-5170-98b3-a88d0fc2f7ae
DOI
10.1101/2020.08.03.235135
Open publication

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