Article
Somatic mutations in human cancer: applications in molecular epidemiology.
Revue d'epidemiologie et de sante publique - 1 Jun 2005
Le Roux E, Gormally E, Hainaut P
Abstract excerpt
The tumour suppressor protein p53 mediates cell-cycle arrest, DNA repair and apoptosis after activation by multiple forms of cellular stresses. When activated, this "master protein" modulates its response depending on the type and intensity of the stress. The TP53 gene with its nearly 20,000 described mutations is the most mutated gene in cancer. Most mutations are missense and occur at over 200 codons within the...
Topics
- Aflatoxin B1
- Apoptosis
- Breast Neoplasms
- Carcinoma, Hepatocellular
- Codon
- DNA Damage
- DNA Fingerprinting
- DNA Repair
- DNA, Neoplasm
- Disease Progression
- Female
- Genes, p53
- Hepatitis B
- Humans
- Liver Neoplasms
- Male
- Molecular Epidemiology
- Mutagens