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Article

p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand.

International journal of cancer - 2 Jan 1993

Hollstein M C, Wild C P, Bleicher F, Chutimataewin S, Harris C C, Srivatanakul P, Montesano R

Abstract excerpt

The prevalence and type of mutations in the p53 tumour-suppressor gene have been determined in 15 hepatocellular carcinomas (HCC) originating from Thailand. Direct sequencing of exons 5-8 revealed 2 mutations, an AGG to AGT (Arg-->Ser) transversion at codon 249, and an ATC-->AAC (Ile-->Asn) transversion at codon 254. Samples from the Thai patients were analyzed for the presence of aflatoxin-liver DNA and...

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Identifiers

PMID: 8380058
DOI: 10.1002/ijc.2910530111

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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