Article
Hepatitis B virus genetic variation and TP53 R249S mutation in patients with hepatocellular carcinoma in Thailand.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Thongbai Chureeporn, Sa-nguanmoo Pattaratida, Kranokpiruk Pavanrat, Poovorawan Kittiyod, Poovorawan Yong, Tangkijvanich Pisit
Abstract excerpt
Chronic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin B1 (AFB1) are major risk factors for hepatocellular carcinoma (HCC). The aim of this study was to evaluate the role of HBV genetic variation and the R249S mutation of the p53 gene, a marker of AFB1-induced HCC, in Thai patients chronically infected with HBV. Sixty-five patients with and 89 patients without HCC were included. Viral...
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