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Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand.

Cancer letters - 30 Apr 2013

Ortiz-Cuaran Sandra, Villar Stephanie, Gouas Doriane, Ferro Gilles, Plymoth Amelie, Khuhaprema Thiravud, Kalalak Anant, Sangrajrang Suleeporn, Friesen Marlin D, Groopman John D, Hainaut Pierre

Abstract excerpt

Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23200676
DOI: 10.1016/j.canlet.2012.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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