Article
TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2009
Szymañska Katarzyna, Chen Jian-Guo, Cui Yan, Gong Yun Yun, Turner Paul Craig, Villar Stéphanie, Wild Christopher Paul, Parkin Donald Maxwell, Hainaut Pierre
Abstract excerpt
Hepatocellular carcinoma (HCC) has a high mortality in East Asia and Sub-Saharan Africa, two regions where the main etiologic factors are chronic infections with hepatitis B virus and dietary exposure to aflatoxin. A single base substitution at the third nucleotide of codon 249 of TP53 (R249S) is common in HCC in these regions and has been associated with aflatoxin-DNA adducts. To determine whether R249S may be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.