Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg).

doi:10.7314/apjcp.2013.14.12.7675

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Article

Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg).

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Chittmittrapap Salyavit, Chieochansin Thaweesak, Chaiteerakij Roongruedee, Treeprasertsuk Sombat, Klaikaew Naruemon, Tangkijvanich Pisit, Komolmit Piyawat, Poovorawan Yong

Abstract excerpt

BACKGROUND: A missense mutation in exon 7 (R249S) of the p53 tumor suppressor gene is characteristic of aflatoxin B1 (AFB1) exposure. AFB1 is believed to have a synergistic effect on hepatitis virus B (HBV) carcinogenesis. However, results of studies comparing R249S prevalence among patients are conflicting. The aim of this study was to determine the prevalence of the R249S mutation in hepatocellular carcinoma...

Topics

Aflatoxins
Carcinoma, Hepatocellular
DNA
DNA, Viral
Female
Follow-Up Studies
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Male

Middle Aged

Mutation

Neoplasm Staging

Poisons

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 24460352
DOI: 10.7314/apjcp.2013.14.12.7675

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