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TP53 R249S mutation detected in circulating tumour DNA is associated with Prognosis of hepatocellular carcinoma patients with or without hepatectomy.

Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2020

Shen Ting, Li Shan-Feng, Wang Jia-Lin, Zhang Ting, Zhang Song, Chen Hai-Tao, Xiao Qian-Yi, Ren Wei-Hua, Liu Chao, Peng Bo, Ji Xiao-Na, Yang Yang, Lu Pei-Xin, Chen Tao-Yang, Yu Long, Ji Yuan, Jiang De-Ke

Abstract excerpt

BACKGROUND AND AIMS: Somatic mutation R249S in TP53 is highly common in hepatocellular carcinoma (HCC). We aim to investigate the effects of R249S in ctDNA on the prognosis of HCC. METHODS: We analysed three cohorts including 895 HCC patients. TP53 mutation spectrum was examined by direct sequencing of genomic DNA from tissue specimens in HCC patients with hepatectomy (Cohort 1, N = 260). R249S and other...

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PMID: 32594568
DOI: 10.1111/liv.14581

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