Article
MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene.
Oncogene - 5 Jun 2014
Yang J, Zhang Z, Chen C, Liu Y, Si Q, Chuang T-H, Li N, Gomez-Cabrero A, Reisfeld R A, Xiang R, Luo Y
Abstract excerpt
One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly expressed by a variety of organisms and are involved in cell behaviors such as suppression or...
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