Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer.

Cell death & disease - 30 Aug 2021

Gu Xiaobin, Shi Yonggang, Dong Meilian, Jiang Li, Yang Jing, Liu Zheyan

Abstract excerpt

The occurrence of radioresistance is a clinical obstacle to endometrial cancer (EC) treatment and induces tumor relapse. In this study, we found that tumor-associated macrophages (TAMs) enriched in EC specimens were determined to present an M2-like phenotype. In vitro, the coculture of M2-polarized macrophages significantly downregulated the radiosensitivity of EC cells by releasing exosomes. Hsa_circ_0001610 was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Cyclin B1
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Mice, Nude

Share to Radiation Tolerance

Share to RNA, Circular

Share to Tumor-Associated Macrophages

Source

Open in PubMed Open full text

Identifiers

PMID: 34462422
DOI: 10.1038/s41419-021-04087-8
PMCID: PMC8405633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer.PMID 34462422Read ↗

Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype.Semantic proximity Read ↗

M1 macrophage-derived exosomal miR-20b promotes radiosensitization in HPV + HNSCSemantic proximity Read ↗

CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype.Semantic proximity Read ↗

Hsa_circ_0102171 aggravates the progression of cervical cancer through targeting miR‐4465/CREBRF axisSemantic proximity Read ↗

M2 macrophage-derived exosomal EHF transcriptionally activates FGFR1 to promote malignant phenotypes and glycolysis in NSCLC.Semantic proximity Read ↗

Exosomal circ‐0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axisSemantic proximity Read ↗

Immune microenvironment and molecular mechanisms in endometrial cancer: implications for resistance and innovative treatmentsSemantic proximity Read ↗

Tumor-derived exosomes in the regulation of macrophage polarization.Semantic proximity Read ↗

Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer ProgressionSemantic proximity Read ↗

M2 Macrophages Crosstalk with Ovarian Cancer Cells by Regulating Cell Ferroptosis via the miR-1228-3p/GPX4 PathwaySemantic proximity Read ↗

Combination of radiosensitivity index and PD-L1 status predicts overall survival of endometrial cancer patients treated with radiotherapy: A study based on TCGA dataSemantic proximity Read ↗

Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.