Article
Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression.
Journal for immunotherapy of cancer - 1 Sept 2020
Wang Liang, Hu Yi-Yang, Zhao Jun-Long, Huang Fei, Liang Shi-Qian, Dong Lei, Chen Yan, Yu Heng-Chao, Bai Jian, Yang Jia-Meng, Fan Jie-Yi, Feng Lei, Li San-Zhong, Han Hua, Qin Hong-Yan
Abstract excerpt
BACKGROUND: Accumulating evidence has shown that tumor-associated macrophages (TAMs) play a critical role in tumor progression. Targeting TAMs is a potential strategy for tumor immunotherapy. However, the mechanism underlying the TAM phenotype and function needs to be resolved. Our previous studies have demonstrated that miR-125a can reverse the TAM phenotype toward antitumor. Meanwhile, we have found that...
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