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MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer

27 May 2021

Abstract excerpt

Many immune suppressive mechanisms utilized by triple negative breast cancer (TNBC) are regulated by oncogenic epithelial-to-mesenchymal transition (EMT). How TNBC EMT impacts innate immune cells is not fully understood. To determine how TNBC suppresses antitumor macrophages, we used microRNA-200c (miR-200c), a powerful repressor of EMT, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells...

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PMID: 34045467
DOI: 10.1038/s41523-021-00273-1

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