Article
In vitro and in vivo evaluation of anti-tumoral effect of M1 phenotype induction in macrophages by miR-130 and miR-33 containing exosomes.
Cancer immunology, immunotherapy : CII - 1 May 2021
Moradi-Chaleshtori Maryam, Bandehpour Mojgan, Soudi Sara, Mohammadi-Yeganeh Samira, Hashemi Seyed Mahmoud
Abstract excerpt
In the tumor microenvironment, macrophages polarize into the M2 phenotype to facilitate tumorigenesis. Tumor-derived exosomes can act as mediators between the tumor microenvironment and stromal cells by transporting proteins, mRNAs, and miRNAs. Exosomal miRNAs play a pivotal role in modulating tumor microenvironment and macrophage polarization. Here, we overexpressed miR-130 and miR-33 in exosomes of MDA-MB-231...
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