Article
Endostatin inhibits the growth and migration of 4T1 mouse breast cancer cells by skewing macrophage polarity toward the M1 phenotype.
Cancer immunology, immunotherapy : CII - 1 Jun 2016
Guo Hua, Liu Yanan, Gu Junlian, Wang Yue, Liu Lianqin, Zhang Ping, Li Yang
Abstract excerpt
The phenotypic diversity of tumor-associated macrophages (TAMs) increases with tumor development. One of the hallmarks of malignancy is the polarization of TAMs from a pro-immune (M1) phenotype to an immunosuppressive (M2) phenotype. However, the molecular basis of this process is still unclear. Endostatin is a powerful inhibitor of angiogenesis capable of suppressing tumor growth and metastasis. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.