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Article

MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.

PloS one - 1 Jan 2013

He Ying, Lian Guili, Lin Shuyong, Ye Zhiyun, Li Qinxi

Abstract excerpt

MDM2 plays a crucial role in negatively regulating the functions of tumor suppressor p53. Here we show that MDM2 can inhibit Axin-stimulated p53-dependent apoptosis by suppressing p53 phosphorylation at Ser 46 and apoptosis-related p53 transactivational activity. Interestingly, the ubiquitin E3 l...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23826318
DOI: 10.1371/journal.pone.0067529
PMCID: PMC3694902

Genes

MDM2
HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23826318-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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