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Strategies for p53 Activation and Targeted Inhibitors of the p53-Mdm2/MdmX Interaction

12 Apr 2025

Abstract excerpt

is a tumor suppressor gene and is regarded as one of the most crucial genes in protecting humans against cancer. The protein Mdm2 and its homolog MdmX serve as negative regulators of p53. In nearly half of cancer cells, there is an overexpression of Mdm2 and MdmX, which inhibit p53 activity. Furthermore, Mdm2's E3 ubiquitin ligase activity promotes the ubiquitination and degradation of p53. Therefore, blocking...

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PMID: 40277907
DOI: 10.3390/cells14080583

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