Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.

Oncogene - 4 Apr 2002

Folberg-Blum Adriana, Sapir Amir, Shilo Ben-Zion, Oren Moshe

Abstract excerpt

The Mdm2 proto-oncogene is amplified and over-expressed in a variety of tumors. One of the major functions of Mdm2 described to date is its ability to modulate the levels and activity of the tumor suppressor protein p53. Mdm2 binds to the N-terminus of p53 and, through its action as an E3 ubiquitin ligase, targets p53 for rapid proteasomal degradation. Mdm2 can also bind to other cellular proteins such as hNumb,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Apoptosis
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Share to Wings, Animal

Source

Identifiers

PMID: 11948425
DOI: 10.1038/sj.onc.1205305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.PMID 11948425Read ↗

Mdm proteins: critical regulators of embryogenesis and homoeostasisSemantic proximity Read ↗

p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens.Semantic proximity Read ↗

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.Semantic proximity Read ↗

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Semantic proximity Read ↗

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesisSemantic proximity Read ↗

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.Semantic proximity Read ↗

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish.Semantic proximity Read ↗

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.Semantic proximity Read ↗

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.Semantic proximity Read ↗

The role of MDM2 and MDM4 in breast cancer development and preventionSemantic proximity Read ↗

Mdm2 and Mdm4 loss regulates distinct p53 activities.Semantic proximity Read ↗

Distinct downstream targets manifest p53-dependent pathologies in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.