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Article

Axin determines cell fate by controlling the p53 activation threshold after DNA damage.

Nature cell biology - 1 Sept 2009

Li Qinxi, Lin Shuyong, Wang Xuan, Lian Guili, Lu Zailian, Guo Huiling, Ruan Ka, Wang Yanhai, Ye Zhiyun, Han Jiahuai, Lin Sheng-Cai

Abstract excerpt

Cells can undergo either cell-cycle arrest or apoptosis after genotoxic stress, based on p53 activity(1-6). Here we show that cellular fate commitment depends on Axin forming distinct complexes with Pirh2, Tip60, HIPK2 and p53. In cells treated with sublethal doses of ultra-violet (UV) radiation or doxorubicin (Dox), Pirh2 abrogates Axin-induced p53 phosphorylation at Ser 46 catalysed by HIPK2, by competing with...

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Source

Identifiers

PMID: 19731416
DOI: 10.1038/ncb1927

Genes

HIPK2
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Axin determines cell fate by controlling the p53 activation threshold after DNA damage.PMID 19731416Read ↗

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.Semantic proximity Read ↗

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cellsSemantic proximity Read ↗

Differential response between the p53 ubiquitin–protein ligases Pirh2 and MdM2 following DNA damage in human cancer cellsSemantic proximity Read ↗

Human PTIP Facilitates ATM-mediated Activation of p53 and Promotes Cellular Resistance to Ionizing RadiationSemantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.Semantic proximity Read ↗

Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Semantic proximity Read ↗

Tip60-mediated acetylation activates transcription independent apoptotic activity of AblSemantic proximity Read ↗

p14<sup>ARF</sup> Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic StressSemantic proximity Read ↗

Phosphorylation of Pirh2 by Calmodulin‐dependent kinase II impairs its ability to ubiquitinate p53Semantic proximity Read ↗

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.Semantic proximity Read ↗

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