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Article

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

21 Mar 2008

Abstract excerpt

The hedgehog (Hh) signaling pathway regulates the development of many organs in mammals, and activation of this pathway is widely observed in human cancers. Although it is known that Hh signaling activates the expression of genes involved in cell growth, the precise role of the Hh pathway in cancer development is still unclear. Here, we show that constitutively activated mutants of Smoothened (Smo), a transducer...

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PMID: 18359851
DOI: 10.1073/pnas.0712216105

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